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If you are not losing weight on GLP-1 therapy , thyroid optimization should be the first thing investigated
[Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
The patient loses weight, including lean mass
The market also sees significant opportunities for expanding the application of GLP-1 receptor agonists beyond diabetes, with emerging research exploring their role in treating heart failure, non-alcoholic steatohepatitis (NASH), and other chronic conditions
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